Recently, the CHINAFLOC researchers published a paper aims to observe acrylamide exposure of rats neurobehavioral and neural electrophysiological changes. Research indicates that rats by intraperitoneal injection of acrylamide can cause nerve behavior and abnormal changes of neural electrophysiology can be induced peripheral neuropathy in rats.
30 SD rats were randomly divided into control group, low dose infected group and high dose infected group, 10 in each group. Low doses of infected group and high dose infected group with 20 mg/kg respectively and 40 mg/kg intraperitoneal injection of acrylamide line, 1 times a day, three times a week, a total of canister to 10 weeks. Observation rat's general status, body weight and gait changes, and nerve conduction velocity and examine each group rats nerve conduction incubation period.
Compared with control group, the acrylamide infected rats weight slow growth, high dose group infected rats weight negative after 8 weeks. Low doses of infected group and high dose of infected rats in eight weeks, 4 weeks respectively peripheral neuropathy abnormal gait, the abnormal gait worse to 10 weeks, the neurobehavioral score values were 2.00 + / - 0.00 and 2.00 + / - 0.00, significantly higher than the control group (P < 0.05). Nerve electrophysiology, according to the results of infected began three weeks rats nerve conduction velocity and nerve conduction lengthen the incubation period, to 10 weeks, low doses of infected group and high dose of infected rats nerve conduction velocity by 15.13% and 33.06% respectively, nerve conduction incubation period extension of 17.41% and 58.75% respectively, compared with control group, the differences were significant (P < 0.05).
Acrylamide is widely used as a kind of industrial chemicals. Some food (such as cookies, chips, bread back against the kind of food) at 120 degrees Celsius under the condition of high temperature and low moisture, can produce acrylamide, especially contain the food of asparagine and reducing sugar.
Acrylamide analysis methods including liquid, gc, selective ion detection or using multiple reaction monitoring of isotope tracer standard of tandem mass spectrometry.
The European food safety authority expert group of food since 2010 of the 43419 results of the analysis are studied, and the conclusion.
The European food chain pollutants team thinks:
According to the current dietary acrylamide exposure without having to worry about the effects of the tumor (not acute poisoning), however although epidemiological association cannot prove that acrylamide is a human carcinogen, but the exposure limits of animal experiments show that need to pay attention to the tumor effect of acrylamide.